LSD1 Rabbit Polyclonal Antibody
LSD1 Rabbit Polyclonal Antibody
Order LSD1 Rabbit Polyclonal Antibody 01011060633 at Gentaur LSD1
Purchase at gentaur.comSize
0.1 mg
Catalog no.
HOM-3763
Price
491 EUR
French translation
anticorps
Latin name
Oryctolagus cuniculus
Group
Polyclonals and antibodies
Properties
If you buy Antibodies supplied by Zyagen they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by Zyagen. Rabbit antibodies are very stable and can be stored for several days at room temperature. Zyagen adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Gene
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.